- Research Centers
- Reproductive Endocrinology Research Center
- Prevention of Metabolic Disorders Research center
- Nutrition and Endocrine Research Center
- Endocrine Physiology Research Center
- Cellular-Molecular Research Center
- Prevention and Treatment of Obesity Research Center
- Endocrine Research Center
- Research Center for Social Determinants of Health
Treatment of osteoporosis Anabolic agents
Treatment of osteoporosis Anabolic agents
S. Kalbasi,M.D
Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Sciences
12 Jun ,2013
Tehran
ANABOLIC AGENTS IN OSTEOPOROSIS TREATMENT
INTRODUCTION :
Two important signals that induce the differentiation of osteoblastic lineage cells into mature osteoblasts are bone orphogenetic proteins and Wnt
Another important regulator of osteoblast function is insulin-like growth factor I (IGF-I).
Anabolic therapeutic agents might be designed to stimulate the actions of these osteoblastic signals directly or to target their extracellular and intracellular regulators.
Signals Determining Mesenchymal-Cell
Differentiation toward Osteoblasts and Signals Acting
on Mature Osteoblasts to Enhance Bone Formation.
MECHANISMS of ANABOLIC AGENTS:
Treatment of osteoporosis
Anabolic agents
S. Kalbasi,M.D
Research Institute for Endocrine Sciences
Shahid Beheshti University of Medical Sciences
12 Jun ,2013
Tehran
ANABOLIC AGENTS IN OSTEOPOROSIS TREATMENT
INTRODUCTION :
Two important signals that induce the differentiation of osteoblastic lineage cells into mature osteoblasts are bone orphogenetic proteins and Wnt
Another important regulator of osteoblast function is insulin-like growth factor I (IGF-I).
Anabolic therapeutic agents might be designed to stimulate the actions of these osteoblastic signals directly or to target their extracellular and intracellular regulators.
Signals Determining Mesenchymal-Cell
Differentiation toward Osteoblasts and Signals Acting
on Mature Osteoblasts to Enhance Bone Formation.
MECHANISMS of ANABOLIC AGENTS:
Osteoblasts, the cells responsible for bone formation, are rational therapeutic anabolic targets.
increase the number of osteoblast precursors.
stimulate the differentiation of osteoblasts into mature cells.
Enhance osteoblastic function or survival.
Finally leads to a net gain of bone tissue.
